Regulation of mechanosensitive biliary epithelial transport by the epithelial Na(+) channel.

ABSTRACT:

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Intrahepatic biliary epithelial cells (BECs), also known as cholangiocytes, modulate the volume and composition of bile through the regulation of secretion and absorption. While mechanosensitive Cl(-) efflux has been identified as an important secretory pathway, the counterabsorptive pathways have not been identified. In other epithelial cells, the epithelial Na(+) channel (ENaC) has been identified as an important contributor to fluid absorption; however, its expression and function in BECs have not been previously studied. Our studies revealed the presence of α, β, and γ ENaC subunits in human BECs and α and γ subunits in mouse BECs. In studies of confluent mouse BEC monolayers, the ENaC contributes to the volume of surface fluid at the apical membrane during constitut

SUBMITTER: Li Q 

PROVIDER: S-EPMC4780683 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature