CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition.

ABSTRACT: The sub-division of the posterior-most territory of the neural plate results in the formation of two distinct neural structures, the hindbrain and the spinal cord. Although many of the molecular signals regulating the development of these individual structures have been elucidated, the mechanisms involved in delineating the boundary between the hindbrain and spinal cord remain elusive. Two molecules, retinoic acid (RA) and the Cdx4 transcription factor have been previously implicated as important regulators of hindbrain and spinal cord development, respectively. Here, we provide evidence that suggests multiple regulatory interactions occur between RA signaling and the Cdx4 transcription factor to establish the anterior-posterior (AP) position of the transition between the hindbrain and spi

SUBMITTER: Chang J 

PROVIDER: S-EPMC4781753 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature