Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals.

ABSTRACT:

Background

Air pollution from particulate matter (PM) has been linked to cardiovascular morbidity and mortality; however the underlying biological mechanisms remain to be uncovered. Gene regulation by microRNAs (miRNAs) that are transferred between cells by extracellular vesicles (EVs) may play an important role in PM-induced cardiovascular risk. This study sought to determine if ambient PM2.5 levels are associated with expression of EV-encapsulated miRNAs (evmiRNAs), and to investigate the participation of such evmiRNAs in pathways related to cardiovascular disease (CVD).

Methods

We estimated the short- (1-day), intermediate- (1-week and 1-month) and long-term (3-month, 6-month, and 1-year) moving averages of ambient PM2.5 levels at participants' addresses using a validated

SUBMITTER: Rodosthenous RS 

PROVIDER: S-EPMC4782360 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature