Metabolic engineering of Escherichia coli for the production of hydroxy fatty acids from glucose.

ABSTRACT:

Background

Hydroxy fatty acids (HFAs) are valuable chemicals for a broad variety of applications. However, commercial production of HFAs has not been established so far due to the lack of low cost routes for their synthesis. Although the microbial transformation pathway of HFAs was extensively studied decades ago, these attempts mainly focused on converting fatty acids or vegetable oils to their hydroxyl counterparts. The use of a wider range of feedstocks to produce HFAs would reduce the dependence on oil crops and be expected to cut down the manufacturing cost.

Results

In this study, the industrially important microorganism Escherichia coli was engineered to produce HFAs directly from glucose. Through the coexpression of the acetyl-CoA carboxylase (ACCase) and the leadless

SUBMITTER: Cao Y 

PROVIDER: S-EPMC4782510 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature