Implications of in vitro dosimetry on toxicological ranking of low aspect ratio engineered nanomaterials.

ABSTRACT: In vitro high throughput screening platforms based on mechanistic injury pathways are been used for hazard assessment of engineered nanomaterials (ENM). Toxicity screening and other in vitro nanotoxicology assessment efforts in essence compare and rank nanomaterials relative to each other. We hypothesize that this ranking of ENM is susceptible to dispersion and dosimetry protocols, which continue to be poorly standardized. Our objective was to quantitate the impact of dosimetry on toxicity ranking of ENM. A set of eight well-characterized and diverse low aspect ratio ENMs, were utilized. The recently developed in vitro dosimetry platform at Harvard, which includes preparation of fairly monodispersed suspensions, measurement of the effective density of formed agglomerates in culture media a

SUBMITTER: Pal AK 

PROVIDER: S-EPMC4782604 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature