Longitudinal and Cross-Sectional Analyses of Age Effects on Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness by Fourier-Domain OCT.

ABSTRACT:

Purpose

We studied the effects of age and intraocular pressure (IOP) on retinal nerve fiber layer (NFL) and macular ganglion cell complex (GCC) thickness in normal eyes.

Methods

Data from subjects from the multicenter Advanced Imaging for Glaucoma Study (AIGS) were analyzed. The data included yearly visits from the normal subjects in the AIGS study. Fourier-domain optical coherence tomography (FD-OCT) was used to measure retinal NFL and macular GCC on each visit. Mixed effect models were used to evaluate the longitudinal effect of age and IOP on the NFL and GCC thickness. The measurements at baseline were used to examine the cross-sectional effects.

Results

The analysis included 192 eyes (92 participants) from AIGS between 2009 and 2013. The longitudinal analyses show

SUBMITTER: Zhang X 

PROVIDER: S-EPMC4782827 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature