Ten-eleven translocation 1 (TET1) methylation is associated with childhood asthma and traffic-related air pollution.

ABSTRACT:

Background

Asthma is a complex disorder influenced by genetics and the environment. Recent findings have linked abnormal DNA methylation in T cells with asthma; however, the potential dysregulation of methylation in airway epithelial cells is unknown. Studies of mouse models of asthma have observed greater levels of 5-hydroxymethylcytosine (5-hmC) and ten-eleven translocation 1 (TET1) expression in lungs. TET proteins are known to catalyze methylation through modification of 5-methylcytosine to 5-hmC.

Objective

We sought to examine the association of TET1 methylation with asthma and traffic-related air pollution (TRAP).

Methods

TET1 methylation levels from DNA derived from nasal airway epithelial cells collected from 12 African American children with physician-diagnos

SUBMITTER: Somineni HK 

PROVIDER: S-EPMC4783231 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature