Quantitative analysis of iontophoretic drug delivery from micropipettes.

ABSTRACT: Microiontophoresis is a drug delivery method in which an electric current is used to eject molecular species from a micropipette. It has been primarily utilized for neurochemical investigations, but is limited due to difficulty controlling and determining the ejected quantity. Consequently the concentration of an ejected species and the extent of the affected region are relegated to various methods of approximation. To address this, we investigated the principles underlying ejection rates and examined the concentration distribution in microiontophoresis using a combination of electrochemical, chromatographic, and fluorescence-based approaches. This involved a principal focus on how the iontophoretic barrel solution affects ejection characteristics. The ion ejection rate displayed a direct

SUBMITTER: Kirkpatrick DC 

PROVIDER: S-EPMC4783294 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature