Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration.

ABSTRACT: A common characteristic of aging is defective regeneration of skeletal muscle. The molecular pathways underlying age-related decline in muscle regenerative potential remain elusive. microRNAs are novel gene regulators controlling development and homeostasis and the regeneration of most tissues, including skeletal muscle. Here, we use satellite cells and primary myoblasts from mice and humans and an in vitro regeneration model, to show that disrupted expression of microRNA-143-3p and its target gene, Igfbp5, plays an important role in muscle regeneration in vitro. We identified miR-143 as a regulator of the insulin growth factor-binding protein 5 (Igfbp5) in primary myoblasts and show that the expression of miR-143 and its target gene is disrupted in satellite cells from old mice. Moreover,

SUBMITTER: Soriano-Arroquia A 

PROVIDER: S-EPMC4783349 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature