Correlates of Protection against Influenza in the Elderly: Results from an Influenza Vaccine Efficacy Trial.

ABSTRACT: Although a number of studies have investigated and quantified immune correlates of protection against influenza in adults and children, data on immune protection in the elderly are sparse. A recent vaccine efficacy trial comparing standard-dose with high-dose inactivated influenza vaccine in persons 65 years of age and older provided the opportunity to examine the relationship between values of three immunologic assays and protection against community-acquired A/H3N2 influenza illness. The high-dose vaccine induced significantly higher antibody titers than the standard-dose vaccine for all assays. For the hemagglutination inhibition assay, a titer of 40 was found to correspond with 50% protection when the assay virus was antigenically well matched to the circulating virus--the same titer a

SUBMITTER: Dunning AJ 

PROVIDER: S-EPMC4783426 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature