The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
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ABSTRACT:
SUBMITTER: Berge T
PROVIDER: S-EPMC4783434 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by vitamin D in CD4+ T cells.
Berge T T Leikfoss I S IS Brorson I S IS Bos S D SD Page C M CM Gustavsen M W MW Bjølgerud A A Holmøy T T Celius E G EG Damoiseaux J J Smolders J J Harbo H F HF Spurkland A A
Genes and immunity 20160114 2
Multiple sclerosis (MS) is an inflammatory, demyelinating disorder of the central nervous system that develops in genetically susceptible individuals. The majority of the MS-associated gene variants are located in genetic regions with importance for T-cell differentiation. Vitamin D is a potent immunomodulator, and vitamin D deficiency has been suggested to be associated with increased MS disease susceptibility and activity. In CD4+ T cells, we have analyzed in vitro vitamin D responsiveness of ...[more]
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