Metabolomic Profiling of Statin Use and Genetic Inhibition of HMG-CoA Reductase.

ABSTRACT:

Background

Statins are first-line therapy for cardiovascular disease prevention, but their systemic effects across lipoprotein subclasses, fatty acids, and circulating metabolites remain incompletely characterized.

Objectives

This study sought to determine the molecular effects of statin therapy on multiple metabolic pathways.

Methods

Metabolic profiles based on serum nuclear magnetic resonance metabolomics were quantified at 2 time points in 4 population-based cohorts from the United Kingdom and Finland (N = 5,590; 2.5 to 23.0 years of follow-up). Concentration changes in 80 lipid and metabolite measures during follow-up were compared between 716 individuals who started statin therapy and 4,874 persistent nonusers. To further understand the pharmacological effects of

SUBMITTER: Wurtz P 

PROVIDER: S-EPMC4783625 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature