Biodegradable Polymers Influence the Effect of Atorvastatin on Human Coronary Artery Cells.

ABSTRACT: Drug-eluting stents (DES) have reduced in-stent-restenosis drastically. Yet, the stent surface material directly interacts with cascades of biological processes leading to an activation of cellular defense mechanisms. To prevent adverse clinical implications, to date almost every patient with a coronary artery disease is treated with statins. Besides their clinical benefit, statins exert a number of pleiotropic effects on endothelial cells (ECs). Since maintenance of EC function and reduction of uncontrolled smooth muscle cell (SMC) proliferation represents a challenge for new generation DES, we investigated the effect of atorvastatin (ATOR) on human coronary artery cells grown on biodegradable polymers. Our results show a cell type-dependent effect of ATOR on ECs and SMCs. We observed pol

SUBMITTER: Strohbach A 

PROVIDER: S-EPMC4783882 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature