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Argonaute and Argonaute-Bound Small RNAs in Stem Cells.

ABSTRACT: Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, including pluripotent, germline, somatic, and cancer stem cells.

SUBMITTER: Zhai L 

PROVIDER: S-EPMC4783940 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Argonaute and Argonaute-Bound Small RNAs in Stem Cells.

Zhai Lihong L   Wang Lin L   Teng Feng F   Zhou Lanting L   Zhang Wenjing W   Xiao Juan J   Liu Ying Y   Deng Wenbin W  

International journal of molecular sciences 20160204 2

Small RNAs are essential for a variety of cellular functions. Argonaute (AGO) proteins are associated with all of the different classes of small RNAs, and are indispensable in small RNA-mediated regulatory pathways. AGO proteins have been identified in various types of stem cells in diverse species from plants and animals. This review article highlights recent progress on how AGO proteins and AGO-bound small RNAs regulate the self-renewal and differentiation of distinct stem cell types, includin  ...[more]

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