Identification of Novel Pathways in Plant Lectin-Induced Cancer Cell Apoptosis.

ABSTRACT: Plant lectins have been investigated to elucidate their complicated mechanisms due to their remarkable anticancer activities. Although plant lectins seems promising as a potential anticancer agent for further preclinical and clinical uses, further research is still urgently needed and should include more focus on molecular mechanisms. Herein, a Naïve Bayesian model was developed to predict the protein-protein interaction (PPI), and thus construct the global human PPI network. Moreover, multiple sources of biological data, such as smallest shared biological process (SSBP), domain-domain interaction (DDI), gene co-expression profiles and cross-species interolog mapping were integrated to build the core apoptotic PPI network. In addition, we further modified it into a plant lectin-induced apo

SUBMITTER: Shi Z 

PROVIDER: S-EPMC4783960 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature