Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study.

ABSTRACT:

Background

In a 2014 cross-sectional analysis, we showed that amyloid and neurodegeneration biomarker states in participants with no clinical impairment varied greatly with age, suggesting dynamic within-person processes. In this longitudinal study, we aimed to estimate rates of transition from a less to a more abnormal biomarker state by age in individuals without dementia, as well as to assess rates of transition to dementia from an abnormal state.

Methods

Participants from the Mayo Clinic Study of Aging (Olmsted County, MN, USA) without dementia at baseline were included in this study, a subset of whom agreed to multimodality imaging. Amyloid PET (with (11)C-Pittsburgh compound B) was used to classify individuals as amyloid positive (A(+)) or negative (A(-)). (18)F-fluoro

SUBMITTER: Jack CR 

PROVIDER: S-EPMC4784263 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature