Hsa-miR-375 is a predictor of local control in early stage breast cancer.

ABSTRACT:

Background

A long-term analysis by the Early Breast Cancer Trialist Group (EBCTG) revealed a strong correlation between local control and cancer-specific mortality. MicroRNAs (miRs), short (20-25 nucleotides) non-coding RNAs, have been described as prognosticators and predictors for breast cancer in recent years. The aim of the current study was to identify miRs that can predict local control after breast conserving therapy (BCT) in early stage breast cancer.

Results

Clinical data of 46 early stage breast cancer patients with local relapse after BCT were selected from the institutional database. These patients were matched to 101 control patients showing identical clinical features but without local relapse. The study was conducted in two steps. (1) In the pilot study, 32 pa

SUBMITTER: Zehentmayr F 

PROVIDER: S-EPMC4784328 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature