A five-gene reverse transcription-PCR assay for pre-operative classification of breast fibroepithelial lesions.

ABSTRACT:

Background

Breast fibroepithelial lesions are biphasic tumors and include fibroadenomas and phyllodes tumors. Preoperative distinction between fibroadenomas and phyllodes tumors is pivotal to clinical management. Fibroadenomas are clinically benign while phyllodes tumors are more unpredictable in biological behavior, with potential for recurrence. Differentiating the tumors may be challenging when they have overlapping clinical and histological features especially on core biopsies. Current molecular and immunohistochemical techniques have a limited role in the diagnosis of breast fibroepithelial lesions. We aimed to develop a practical molecular test to aid in distinguishing fibroadenomas from phyllodes tumors in the pre-operative setting.

Methods

We profiled the transcripto

SUBMITTER: Tan WJ 

PROVIDER: S-EPMC4784364 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature