Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice.

ABSTRACT:

Background

Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities for causing disseminated disease in the blood of C3H/HeJ mice during early infection.

Results

B. burgdorferi B515, a clinical isolate that causes disseminated infection in mice, differentially regulated 236 transcripts (P < 0.05 by ANOVA, with fold change of at least 2). The 216 significantly induced transcripts included interferon (IFN)-responsive genes and genes involved in immunity and inflammation. In contrast, B. burgdorferi B331, a clinical isolate that causes transient skin infection but does not disseminate in C3H/HeJ mice, stimulated changes in o

SUBMITTER: Petzke MM 

PROVIDER: S-EPMC4784397 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature