The agr function and polymorphism: impact on Staphylococcus aureus susceptibility to photoinactivation.

ABSTRACT: Staphylococcus aureus is an important human pathogen that causes healthcare-associated and community-acquired infections. Moreover, the growing prevalence of multiresistant strains requires the development of alternative methods to antibiotic therapy. One effective therapeutic option may be antimicrobial photodynamic inactivation (aPDI). Recently, S. aureus strain-dependent response to PDI was demonstrated, although the mechanism underlying this phenomenon remains unexplained. The aim of the current study was to investigate statistically relevant correlations between the functionality and polymorphisms of agr gene determined for 750 methicillin-susceptible and methicillin-resistant S. aureus strains and their responses to photodynamic inactivation using protoporphyrin IX. An AluI and RsaI

SUBMITTER: Grinholc M 

PROVIDER: S-EPMC4784427 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature