Salmonella Typhimurium undergoes distinct genetic adaption during chronic infections of mice.

ABSTRACT:

Background

Typhoid fever caused by Salmonella enterica serovar Typhi (S. Typhi) is a severe systemic human disease and endemic in regions of the world with poor drinking water quality and sewage treatment facilities. A significant number of patients become asymptomatic life-long carriers of S. Typhi and serve as the reservoir for the disease. The specific mechanisms and adaptive strategies enabling S. Typhi to survive inside the host for extended periods are incompletely understood. Yet, elucidation of these processes is of major importance for improvement of therapeutic strategies. In the current study genetic adaptation during experimental chronic S. Typhimurium infections of mice, an established model of chronic typhoid fever, was probed as an approach for studying the molecular

SUBMITTER: Sondberg E 

PROVIDER: S-EPMC4784465 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature