Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets.

ABSTRACT: Obesity and its comorbidities, including type 2 diabetes mellitus and cardiovascular disease, are associated with a state of chronic low-grade inflammation that can be detected both systemically and within specific tissues. Areas of active investigation focus on the molecular bases of metabolic inflammation and potential pathogenic roles in insulin resistance, diabetes, and cardiovascular disease. An increased accumulation of macrophages occurring in obese adipose tissue has emerged as a key process in metabolic inflammation. Recent studies have also begun to unravel the heterogeneity of adipose tissue macrophages, and their physical and functional interactions with adipocytes, endothelial cells, and other immune cells within the adipose tissue microenvironment. Translating the information

SUBMITTER: Romeo GR 

PROVIDER: S-EPMC4784686 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature