Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization.

ABSTRACT:

Objective

To validate independent associations between branched-chain amino acids (BCAA) and other metabolites with coronary artery disease (CAD).

Methods

We conducted mass-spectrometry-based profiling of 63 metabolites in fasting plasma from 1983 sequential patients undergoing cardiac catheterization. Significant CAD was defined as CADindex ≥ 32 (at least one vessel with ≥ 95% stenosis; N = 995) and no CAD as CADindex ≤ 23 and no previous cardiac events (N = 610). Individuals (N = 378) with CAD severity between these extremes were excluded. Principal components analysis (PCA) reduced large numbers of correlated metabolites into uncorrelated factors. Association between metabolite factors and significant CAD vs. no CAD was tested using logistic regression; and between metabo

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC4784695 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature