Disrupted balance of T cells under natalizumab treatment in multiple sclerosis.

ABSTRACT:

Objective

To compare effects of natalizumab on inflammatory and regulatory T cells with regard to expression of α4-integrin (CD49d).

Methods

Twenty-seven natalizumab-naive and 8 natalizumab-treated patients with multiple sclerosis (MS), 7 patients with neuromyelitis optica (NMO) or NMO spectrum disorder, and 8 healthy controls were included. The positive rate of CD49d was analyzed and compared among T helper 1 (Th1), T helper 17 (Th17), and regulatory T (Treg) cells (CD49d+Th1, CD49d+Th17, and CD49d+Treg, respectively).

Results

Natalizumab treatment increased CD49d ratios, CD49d+Th1/CD49d+Treg, and CD49d+Th17/CD49d+Treg. This indicates larger reduction of the CD49d+ population in Treg cells than in Th1 or Th17 cells. The CD49d ratios of 2 patients who experienced exac

SUBMITTER: Kimura K 

PROVIDER: S-EPMC4784802 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature