Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching.

ABSTRACT:

Background

An essential component of evaluating potential modified risk tobacco products is to determine how consumers use the product and resulting effects on biomarkers of toxicant exposure.

Study design

Cigarette smokers (n=391) recruited in Minnesota and Oregon were randomised to either snus or 4 mg nicotine gum for 12 weeks. Participants were instructed to completely switch from cigarettes to these products. Urine samples were collected to analyse for carcinogenic tobacco-specific nitrosamine metabolites (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and N'-nitrosonornicotine and their glucuronides) and nicotine metabolites (total cotinine and nicotine equivalents) levels.

Results

Of the 391 participants randomised, 52.9% were male, the mean±SD age was 43.9±12.5 

SUBMITTER: Hatsukami DK 

PROVIDER: S-EPMC4785094 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature