Dataset Information

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

ABSTRACT: Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease.

SUBMITTER: Page K

PROVIDER: S-EPMC4785397 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature

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Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Page Kimberly K Mirzazadeh Ali A Rice Thomas M TM Grebely Jason J Kim Arthur Y AY Cox Andrea L AL Morris Meghan D MD Hellard Margaret M Bruneau Julie J Shoukry Naglaa H NH Dore Gregory J GJ Maher Lisa L Lloyd Andrew R AR Lauer Georg G Prins Maria M McGovern Barbara H BH

Open forum infectious diseases 20160101 1

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease. ...[more]

PMID: 26973850

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Project description:IFNL4-?G/TT (rs368234815) genotype is associated with hepatitis C virus clearance and may play a role in other infections. IFN-?4 protein is generated only in individuals who carry the IFNL4-?G allele. The IFNL4 rs12979860-T allele, which is in strong linkage disequilibrium with IFNL4-?G, was recently reported to be associated with more frequent and severe oral herpes episodes. We investigated the association of IFNL4-?G/TT with herpes simplex virus (HSV)-related outcomes among 2,192 African American and European American participants in the Women's Interagency HIV Study (WIHS). WIHS is a prospective cohort study of human immunodeficiency virus (HIV)-infected and at-risk women that began in 1994. This report includes follow-up through 2013. Available data included: HSV-1 and HSV-2 antibodies at study entry; bi-annually ascertained episodes of (self-reported) oral herpes, (self-reported) genital sores and (clinician-observed) genital ulcers; HSV-2 DNA in cervicovaginal lavage (CVL) specimens. IFNL4-?G/TT genotyping was determined by TaqMan. We compared women with IFNL4-?G/?G or IFNL4-TT/?G genotypes (i.e., IFNL4-?G carriers) to those with the IFNL4-TT/TT genotype, adjusting for age, race and HIV status. For outcomes with repeated measurements, the adjusted odds ratio (aOR), 95% confidence interval [CI] and p-value were determined using a generalized estimating equations approach. Median participant age at enrollment was 36 years; 81% were African American, 74% were HIV-infected. Among 1,431 participants tested for antibodies, 72.8% were positive for HSV-1 and 79.0% were positive for HSV-2. We observed no association between IFNL4-?G/TT genotype and any outcome: HSV-1 or HSV-2 antibody prevalence (p>0.1, all comparisons); oral herpes (aOR, 1.2; p = 0.35); genital sores (aOR, 1.0; p = 0.71); genital ulcers (aOR, 1.1; p = 0.53); detectable HSV-2 DNA in CVL (N = 322; aOR, 0.71; p = 0.49); HSV-2 DNA level (p = 0.68). In this large prospective study, IFNL4-?G/TT genotype was not associated with HSV-related outcomes, including episodes of oral or genital herpes.

Dataset Information

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

Publications

Interferon Lambda 4 Genotype Is Associated With Jaundice and Elevated Aminotransferase Levels During Acute Hepatitis C Virus Infection: Findings From the InC3 Collaborative.

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