Cognitive effects of adjunctive perampanel for partial-onset seizures: A randomized trial.

ABSTRACT:

Objective

Assess cognitive effects of adjunctive perampanel in adolescents.

Methods

In this double-blind study (ClinicalTrials.gov identifier: NCT01161524), patients aged 12 to <18 years with partial-onset seizures despite receiving 1-3 antiepileptic drugs were randomized (2:1) to perampanel or placebo. Perampanel was increased weekly in 2-mg increments to 8-12 mg/day (6-week titration; 13-week maintenance). Changes in neuropsychological outcomes were assessed at end of maintenance: Cognitive Drug Research (CDR) System Global Cognition Score (primary end point), five CDR System domain T-scores (secondary end points), letter fluency, category fluency, and Lafayette Grooved Pegboard Test (LGPT).

Results

One hundred thirty-three patients were randomized. In the full anal

SUBMITTER: Meador KJ 

PROVIDER: S-EPMC4785606 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature