Clinical and subclinical endometritis induced alterations in bovine endometrial transcriptome and miRNome profile.

ABSTRACT:

Background

Clinical and subclinical endometritis are known to affect the fertility of dairy cows by inducing uterine inflammation. We hypothesized that clinical or subclinical endometritis could affect the fertility of cows by disturbing the molecular milieu of the uterine environment. Here we aimed to investigate the endometrial molecular signatures and pathways affected by clinical and subclinical endometritis. For this, Holstein Frisian cows at 42-60 days postpartum were classified as healthy (HE), subclinical endometritis (SE) or clinical endometritis (CE) based on veterinary clinical examination of the animals and histological evaluation the corresponding endometrial biopsies. Endometrial transcriptome and miRNome profile changes and associated molecular pathways induced by su

SUBMITTER: Salilew-Wondim D 

PROVIDER: S-EPMC4785637 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature