Lack of association between MTHFR C677T polymorphism and breast cancer risk in Ahvaz, west south-Iran.

ABSTRACT:

Background

Association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism and DNA methylation, and breast cancer risk are inconsistent. We investigated in a case-control study, possible effect of the common MTHFR C677T polymorphism on breast cancer risk in a sample of Iranian patients.

Materials and methods

The study subjects comprised of 123 breast cancer cases and 110 cancer-free control, who were matched for age and body mass index (BMI). C677T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Lipid profile was measured in all subjects by standard method.

Results

The genotypes distributions (CC, CT, and TT) were 55.3, 39, and 5.7% i

SUBMITTER: Mohammadzadeh G 

PROVIDER: S-EPMC4785787 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature