HIV-1 Capsid Inhibitors as Antiretroviral Agents.

ABSTRACT:

Background

The infectious human immunodeficiency virus (HIV) particle is characterized by a conical capsid that encloses the viral RNA genome. The capsid is essential for HIV-1 replication and plays crucial roles in both early and late stages of the viral life cycle. Early on, upon fusion of the viral and cellular membranes, the viral capsid is released into the host cell cytoplasm and dissociates in a process known as uncoating, tightly associated with the reverse transcription of the viral genome. During the late stages of viral replication, the Gag polyprotein, precursor of the capsid protein, assemble at the plasma membrane to form immature non-infectious viral particles. After a maturation step by the viral protease, the capsid assembles to form a fullerene-like conical shape

SUBMITTER: Thenin-Houssier S 

PROVIDER: S-EPMC4785820 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature