Topologically Reorganized Connectivity Architecture of Default-Mode, Executive-Control, and Salience Networks across Working Memory Task Loads.

ABSTRACT: The human brain is topologically organized into a set of spatially distributed, functionally specific networks. Of these networks, the default-mode network (DMN), executive-control network (ECN), and salience network (SN) have received the most attention recently for their vital roles in cognitive functions. However, very little is known about whether and how the interactions within and between these 3 networks would be modulated by cognitive demands. Here, we employed graph-based modularity analysis to identify the DMN, ECN, and SN during an N-back working memory (WM) task and further investigated the modulation of intra- and inter-network interactions at different cognitive loads. As the task load elevated, functional connectivity decreased within the DMN while increased within the ECN,

SUBMITTER: Liang X 

PROVIDER: S-EPMC4785946 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature