Dataset Information
Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab.
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ABSTRACT:
SUBMITTER: Roth DA
PROVIDER: S-EPMC4785993 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Publications
Elevated BLyS levels in patients with systemic lupus erythematosus: Associated factors and responses to belimumab.
Lupus 20150918 4
<h4>Introduction</h4>Patients with systemic lupus erythematosus (SLE) with B-lymphocyte stimulator (BLyS) levels ≥ 2 ng/mL are at increased risk of flare. A regression analysis was undertaken to identify routine clinical measures that correlate with BLyS ≥ 2 ng/mL. Efficacy and safety of belimumab 10 mg/kg were examined in patients with BLyS ≥ 2 ng/mL and < 2 ng/mL.<h4>Methods</h4>Data from BLISS-52 and -76 (N = 1684) were pooled post hoc. A univariate logistic regression was employed to identif ...[more]