Integrating Transgenic Vector Manipulation with Clinical Interventions to Manage Vector-Borne Diseases.

ABSTRACT: Many vector-borne diseases lack effective vaccines and medications, and the limitations of traditional vector control have inspired novel approaches based on using genetic engineering to manipulate vector populations and thereby reduce transmission. Yet both the short- and long-term epidemiological effects of these transgenic strategies are highly uncertain. If neither vaccines, medications, nor transgenic strategies can by themselves suffice for managing vector-borne diseases, integrating these approaches becomes key. Here we develop a framework to evaluate how clinical interventions (i.e., vaccination and medication) can be integrated with transgenic vector manipulation strategies to prevent disease invasion and reduce disease incidence. We show that the ability of clinical interventions

SUBMITTER: Okamoto KW 

PROVIDER: S-EPMC4786096 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature