The Formulation of Bacteriophage in a Semi Solid Preparation for Control of Propionibacterium acnes Growth.

ABSTRACT:

Aims

To isolate and characterise phage which could lyse P. acnes and to formulate the phage into a delivery form for potential application in topical treatment of acne infection.

Methods and results

Using standard phage isolation techniques, ten phage capable of lysing P. acnes were isolated from human skin microflora. Their genomes showed high homology to previously reported P. acnes phage. These phage were formulated into cetomacrogol cream aqueous at a concentration of 2.5x108 PFU per gram, and shown to lyse underlying P. acnes cells grown as lawn cultures. These phage formulations remained active for at least 90 days when stored at four degrees Celsius in a light protected container.

Conclusions

P. acnes phage formulated into cetomacrogol cream aqueous will lyse s

SUBMITTER: Brown TL 

PROVIDER: S-EPMC4786141 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature