The Acute Respiratory Distress Syndrome: Mechanisms and Perspective Therapeutic Approaches.

ABSTRACT: Acute Respiratory Distress Syndrome (ARDS) is a severe lung inflammatory disorder with a 30-50% mortality. Sepsis and pneumonia are the leading causes of ARDS. On the cellular level there is pulmonary capillary endothelial cell permeability and fluid leakage into the pulmonary parenchyma, followed by neutrophils, cytokines and an acute inflammatory response. When fluid increases in the interstitium then the outward movement continues and protein rich fluid floods the alveolar spaces through the tight junctions of the epithelial cells. Neutrophils play an important role in the development of pulmonary edema associated with acute lung injury or ARDS. Animal studies have shown that endothelial injury appears within minutes to hours after Acute Lung Injury (ALI) initiation with resulting inter

SUBMITTER: Gonzales JN 

PROVIDER: S-EPMC4786180 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature