Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice.

ABSTRACT: Prox1 heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We characterized the lymphatics of Prox1^+/- mice to determine whether the extent of obesity correlated with the severity of lymphatic defects. The lymphatic vasculature in Prox1^+/- mice exhibited reduced tracer clearance from the ear skin, dysfunctional perfusion of the lower legs, and reduced tracer uptake into the deep lymphatic collectors during mechanostimulation prior to the onset of obesity. Ear lymphatic vessels and leg collectors in Prox1^+/- mice were disorganized and irregular, further confirmi

SUBMITTER: Escobedo N 

PROVIDER: S-EPMC4786184 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature