Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs.

ABSTRACT: Since the first Hodgkin and Huxley ion channel model was described in the 1950s, there has been an explosion in mathematical models to describe ion channel function. As experimental data has become richer, models have concomitantly been improved to better represent ion channel kinetic processes, although these improvements have generally resulted in more model complexity and an increase in the number of parameters necessary to populate the models. Models have also been developed to explicitly model drug interactions with ion channels. Recent models of drug-channel interactions account for the discrete kinetics of drug interaction with distinct ion channel state conformations, as it has become clear that such interactions underlie complex emergent kinetics such as use-dependent block. Here,

SUBMITTER: Moreno JD 

PROVIDER: S-EPMC4786197 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature