Association of Macroeconomic Factors With Nonrelapse Mortality After Allogeneic Hematopoietic Cell Transplantation for Adults With Acute Lymphoblastic Leukemia: An Analysis From the Acute Leukemia Working Party of the EBMT.

ABSTRACT:

Purpose

From a global perspective, the rates of allogeneic hematopoietic cell transplantation (alloHCT) are closely related to the economic status of a country. However, a potential association with outcome has not yet been documented. The goal of this study was to evaluate effects of health care expenditure (HCE), Human Development Index (HDI), team density, and center experience on nonrelapse mortality (NRM) after HLA-matched sibling alloHCT for adults with acute lymphoblastic leukemia (ALL).

Patients and methods

A total of 983 patients treated with myeloablative alloHCT between 2004 and 2008 in 24 European countries were included.

Results

In a univariate analysis, the probability of day 100 NRM was increased for countries with lower current HCE (8% vs. 3%; p = .06)

SUBMITTER: Giebel S 

PROVIDER: S-EPMC4786353 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature