Sports genetics: the PPARA gene and athletes' high ability in endurance sports. A systematic review and meta-analysis.

ABSTRACT:

Unlabelled

A meta-analysis was performed with the aim of re-evaluating the role of the peroxisome proliferator activated receptor alpha (PPARA) gene intron 7 G/C polymorphism (rs4253778) in athletes' high ability in endurance sports.

Design

A meta-analysis of case control studies assessing the association between the G/C polymorphisms of the PPARA gene and endurance sports was conducted. The Cochrane Review Manager software was used to compare the genotype and allele frequencies between endurance athletes and controls to determine whether a genetic variant is more common in athletes than in the general population. Five studies, encompassing 760 endurance athletes and 1792 controls, fulfilled our inclusion criteria. The pooled odds ratio (and confidence intervals, CIs) for th

SUBMITTER: Lopez-Leon S 

PROVIDER: S-EPMC4786580 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature