Ontology highlight
ABSTRACT:
SUBMITTER: Osborn MJ
PROVIDER: S-EPMC4786913 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20151027 3
Present adoptive immunotherapy strategies are based on the re-targeting of autologous T-cells to recognize tumor antigens. As T-cell properties may vary significantly between patients, this approach can result in significant variability in cell potency that may affect therapeutic outcome. More consistent results could be achieved by generating allogeneic cells from healthy donors. An impediment to such an approach is the endogenous T-cell receptors present on T-cells, which have the potential to ...[more]