Ontology highlight
ABSTRACT:
SUBMITTER: Turunen TA
PROVIDER: S-EPMC4786919 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Turunen Tytteli A K TA Kurkipuro Jere J Heikura Tommi T Vuorio Taina T Hytönen Elisa E Izsvák Zsuzsanna Z Ylä-Herttuala Seppo S
Molecular therapy : the journal of the American Society of Gene Therapy 20151216 3
Plasmid-based Sleeping Beauty (SB) transposon vectors were developed and used to deliver genes for low-density lipoprotein and very-low-density lipoprotein receptors (LDLR and VLDLR, respectively) or lacZ reporter into liver of an LDLR-deficient mouse model of familial hypercholesterolemia (FH). SB transposase, SB100x, was used to integrate the therapeutic transposons into mice livers for evaluating the feasibility of the vectors in reducing high blood cholesterol and the progression of atherosc ...[more]