Systems biology of the structural proteome.

ABSTRACT:

Background

The success of genome-scale models (GEMs) can be attributed to the high-quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional regulatory networks on an organism-specific basis. Such reconstructions are biochemically, genetically, and genomically structured knowledge bases that can be converted into a mathematical format to enable a myriad of computational biological studies. In recent years, genome-scale reconstructions have been extended to include protein structural information, which has opened up new vistas in systems biology research and empowered applications in structural systems biology and systems pharmacology.

Results

Here, we present the generation, application, and dissemination of genome-scale models with protein stru

SUBMITTER: Brunk E 

PROVIDER: S-EPMC4787049 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature