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Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.

ABSTRACT: Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age- and growth-discriminatory taxa from the microbiota of the former were able to invade that of the latter, which prevented growth impairments in recipient animals. Adding two invasive species, Ruminococcus gnavus and Clostridium symbiosum, to the microbiota from undernourished donors also ameliorated growth and metabolic abnormalities in recipient animals. These results provide evidence that microbiota immaturity is causally related to undernutrition and reveal potential therapeutic targets and agents.

SUBMITTER: Blanton LV

PROVIDER: S-EPMC4787260 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.

Blanton Laura V LV Charbonneau Mark R MR Salih Tarek T Barratt Michael J MJ Venkatesh Siddarth S Ilkaveya Olga O Subramanian Sathish S Manary Mark J MJ Trehan Indi I Jorgensen Josh M JM Fan Yue-Mei YM Henrissat Bernard B Leyn Semen A SA Rodionov Dmitry A DA Osterman Andrei L AL Maleta Kenneth M KM Newgard Christopher B CB Ashorn Per P Dewey Kathryn G KG Gordon Jeffrey I JI

Science (New York, N.Y.) 20160201 6275

Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morp ...[more]

PMID: 26912898

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Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.

Publications

Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children.

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