Persistent Infections by Nontyphoidal Salmonella in Humans: Epidemiology and Genetics.

ABSTRACT:

Background

Although chronic infections by typhoidal Salmonella are well-known, prolonged human infections by nontyphoidal Salmonella (NTS) are poorly characterized.

Methods

We retrospectively analyzed 48 345 culture-confirmed NTS infections that occurred in Israel 1995-2012. A case-control study was performed to identify risk factors associated with persistent infections. Whole-genome-sequencing, pulsed-field gel electrophoresis (PFGE), and a mouse infection model were used to study genetic and phenotypic differences between same-patient persistent, recurring isolates.

Results

In total, 1047 cases of persistent NTS infections, comprising 2.2% of all reported cases of salmonellosis, were identified. The persistence periods ranged between 30 days to 8.3 years. The major

SUBMITTER: Marzel A 

PROVIDER: S-EPMC4787607 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature