Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM).

ABSTRACT: Microbial natural products are an invaluable source of evolved bioactive small molecules and pharmaceutical agents. Next-generation and metagenomic sequencing indicates untapped genomic potential, yet high rediscovery rates of known metabolites increasingly frustrate conventional natural product screening programs. New methods to connect biosynthetic gene clusters to novel chemical scaffolds are therefore critical to enable the targeted discovery of genetically encoded natural products. Here, we present PRISM, a computational resource for the identification of biosynthetic gene clusters, prediction of genetically encoded nonribosomal peptides and type I and II polyketides, and bio- and cheminformatic dereplication of known natural products. PRISM implements novel algorithms which render it

SUBMITTER: Skinnider MA 

PROVIDER: S-EPMC4787774 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature