Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.

ABSTRACT: Leishmaniasis comprises an array of diseases caused by pathogenic species of Leishmania, resulting in a spectrum of mild to life-threatening pathologies. Currently available therapies for leishmaniasis include a limited selection of drugs. This coupled with the rather fast emergence of parasite resistance, presents a dire public health concern. Paromomycin (PAR), a broad-spectrum aminoglycoside antibiotic, has been shown in recent years to be highly efficient in treating visceral leishmaniasis (VL)-the life-threatening form of the disease. While much focus has been given to exploration of PAR activities in bacteria, its mechanism of action in Leishmania has received relatively little scrutiny and has yet to be fully deciphered. In the present study we present an X-ray structure of PAR boun

SUBMITTER: Shalev M 

PROVIDER: S-EPMC4787808 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature