MiRComb: An R Package to Analyse miRNA-mRNA Interactions. Examples across Five Digestive Cancers.

ABSTRACT: MicroRNAs (miRNAs) are small RNAs that regulate the expression of target mRNAs by specific binding on the mRNA 3'UTR and promoting mRNA degradation in the majority of cases. It is often of interest to know the specific targets of a miRNA in order to study them in a particular disease context. In that sense, some databases have been designed to predict potential miRNA-mRNA interactions based on hybridization sequences. However, one of the main limitations is that these databases have too many false positives and do not take into account disease-specific interactions. We have developed an R package (miRComb) able to combine miRNA and mRNA expression data with hybridization information, in order to find potential miRNA-mRNA targets that are more reliable to occur in a specific physiological o

SUBMITTER: Vila-Casadesus M 

PROVIDER: S-EPMC4788200 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature