The Role of Adherence and Retreatment in De Novo Emergence of MDR-TB.

ABSTRACT: Treatment failure after therapy of pulmonary tuberculosis (TB) infections is an important challenge, especially when it coincides with de novo emergence of multi-drug-resistant TB (MDR-TB). We seek to explore possible causes why MDR-TB has been found to occur much more often in patients with a history of previous treatment. We develop a mathematical model of the replication of Mycobacterium tuberculosis within a patient reflecting the compartments of macrophages, granulomas, and open cavities as well as parameterizing the effects of drugs on the pathogen dynamics in these compartments. We use this model to study the influence of patient adherence to therapy and of common retreatment regimens on treatment outcome. As expected, the simulations show that treatment success increases with incre

SUBMITTER: Cadosch D 

PROVIDER: S-EPMC4788301 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature