PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.

ABSTRACT:

Objective

The aim of this study is to identify single-nucleotide polymorphisms (SNPs) influencing blood pressure (BP) response to the β-blocker atenolol.

Methods

Genome-wide association analysis of BP response to atenolol monotherapy was performed in 233 white participants with uncomplicated hypertension in the pharmacogenomic evaluation of antihypertensive responses study. Forty-two polymorphisms with P less than 10 for association with either diastolic or systolic response to atenolol monotherapy were validated in four independent groups of hypertensive individuals (total n = 2114).

Results

In whites, two polymorphisms near the gene PTPRD (rs12346562 and rs1104514) were associated with DBP response to atenolol (P = 3.2 × 10 and P = 5.9 × 10, respectively) with direc

SUBMITTER: Gong Y 

PROVIDER: S-EPMC4788379 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature