A multicenter randomized trial of computer-driven protocolized weaning from mechanical ventilation.

ABSTRACT:

Rationale and objectives

Duration of weaning from mechanical ventilation may be reduced by the use of a systematic approach. We assessed whether a closed-loop knowledge-based algorithm introduced in a ventilator to act as a computer-driven weaning protocol can improve patient outcomes as compared with usual care.

Methods and measurements

We conducted a multicenter randomized controlled study with concealed allocation to compare usual care for weaning with computer-driven weaning. The computerized protocol included an automatic gradual reduction in pressure support, automatic performance of spontaneous breathing trials (SBT), and generation of an incentive message when an SBT was successfully passed. One hundred forty-four patients were enrolled before weaning initiation. The

SUBMITTER: Lellouche F 

PROVIDER: S-EPMC4788698 | biostudies-literature | 2006 Oct

REPOSITORIES: biostudies-literature